Structural insights into the activation and inhibition of the ADAM17–iRhom2 complex

Proceedings of the National Academy of Sciences, Volume 122, Issue 24, June 2025.
SignificanceADAM (a disintegrin and metalloproteinase)-17 is a crucial enzyme that activates proteins involved in development, immune defense, and tissue repair. Its dysregulation is linked to diseases such as cancer, autoimmune conditions, and COVID-19…
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