SNORD80-guided 2’-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses

Proceedings of the National Academy of Sciences, Volume 122, Issue 7, February 2025.
SignificanceHere, we report that the C/D Box snoRNA SNORD80, which is encoded by an intron of theGAS5gene, guides 2′-O-methylation of the lncRNA GAS5, leading to its stabilization and consequent upregulation, and thus plays a role in regulating the …
Read More