S-Nitrosylation of CRTC1 in Alzheimer’s disease impairs CREB-dependent gene expression induced by neuronal activity

Proceedings of the National Academy of Sciences, Volume 122, Issue 9, March 2025.
SignificanceThis study highlights the significance of protein S-nitrosylation, specifically of CRTC1, a cAMP response element-binding protein (CREB) transcriptional coactivator, in the context of Alzheimer’s disease (AD). In the normal brain, CRTC1 plays …
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