Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation

Proceedings of the National Academy of Sciences, Volume 122, Issue 36, September 2025.
SignificanceMitochondrial dysfunction is a hallmark of cancer, driving dedifferentiation and progression. Here, we introduce a mitochondria-centric differentiation therapy that combines retinoic acid (RA) with a mitochondrial uncoupler to restore …
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