Proteasome stress activates YAP/TAZ through the RAP2–MAP4Ks–LATS1/2 pathway and its therapeutic implications in solid tumors

Proceedings of the National Academy of Sciences, Volume 122, Issue 51, December 2025.
SignificanceThis study identifies proteasome stress as an upstream regulator of the Hippo signaling pathway. We show that proteasome stress causes ubiquitination of RAP2, leading to its inactivation, which in turn suppresses the MAP4Ks–NF2–LATS1/2 cascade …
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