Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer

Proceedings of the National Academy of Sciences, Volume 122, Issue 43, October 2025.
SignificanceLamin A/C, a key structural component of the nuclear envelope, is frequently lost or mutated in cancer, laminopathies, and aging-related disorders. We show thatLMNAloss disrupts nuclear pore complex organization and impairs RNA export…
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