MBNL loss of function in smooth muscle as a model for myotonic dystrophy associated gastrointestinal dysmotility

Proceedings of the National Academy of Sciences, Volume 122, Issue 50, December 2025.
SignificanceGastrointestinal (GI) dysfunction is a prevalent yet understudied feature of myotonic dystrophy type 1 (DM1), affecting the quality of life for most affected individuals. We developed smooth muscle-specificMbnlknockout mice to investigate …
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