Joubert syndrome 26 protein enforces compartmentalized motility of a ciliary kinesin

Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025.
SignificanceCilia dysfunction, including impaired intraflagellar transport (IFT), underlies ciliopathies like Joubert syndrome. InCaenorhabditis elegans, kinesin-II and OSM-3 drive IFT in the middle ciliary segment, while only OSM-3 operates distally. …
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